Revisiting the mechanism of P450 enzymes with the radical clocks norcarane and spiro[2,5]octane

Authors :: Auclair, Karine
Hu, Zhengbo
Little, Dorothy M.
Montellano, Paul R. Ortiz De
Groves, John T.
Source :: Journal of the American Chemical Society. May 29, 2002, Vol. 124 Issue 21, 6020-6027
Publication Year :: 2002
Abstract: Noncarane and spiro[2.5]octane are used to determine the mechanisms of hydrocarbon hydroxylation by two mammalian and two bacterial cytochrome P450 enzymes. Results present a consistent pattern of rearrangement that supports a radical rebound mechanism for this set of cytochrome P450 enzymes.

Subjects :: Cytochromes -- Research
Hydroxylation -- Research
Enzymes -- Research
Enzymes -- Chemical properties
Chemistry

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