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A theoretical study on the mechanism of camphor hydroxylation by compound I of cytochrome P450
- Source :
- Journal of the American Chemical Society. April 16, 2003, Vol. 125 Issue 15, p4652, 10 p.
- Publication Year :
- 2003
-
Abstract
- Mechanistic and energetic aspects for the conversion of camphor to 5-exo-hydroxycamphor by the compound I iron-oxo species of cytochrome P450 are discussed from B3LYP DFT calculations. The reaction occurs in a two-step manner along the lines that the oxygen rebound mechanism suggests.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 125
- Issue :
- 15
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.123710979