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Conformational analysis of a stereochemically complete set of cis-anediol peptide analogues

Authors :
Michielin, Olivier
Zoete, Vincent
Gierasch, Tiffany Malinky
Eckstein, Jens
Napper, Andrew
Verdine Gregory
Karplus, Martin
Source :
Journal of the American Chemical Society. Sept 18, 2002, Vol. 124 Issue 37, p11131, 11 p.
Publication Year :
2002

Abstract

A conformational analysis of a stereochemically complete set of peptide analogues based on a cis-enediol unit is presented. The ability of each of the stereoisomers to mimic natural peptides, evaluated by this method, is correlated with its experimental activity in a renin inhibition assay.

Details

Language :
English
ISSN :
00027863
Volume :
124
Issue :
37
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.123659834