Asymmetric skeletal rearrangement of symmetrically alpha,alpha-distributed alpha-amino aldehydes: a new entry to optically active alpha-hydroxy ketones

Authors :: Ooi, Takashi
Saito, Akira
Maruoka, Keiji
Mioskowski, Charles
Falck, J.R.
Source :: Journal of the American Chemical Society. March 19, 2003, Vol. 125 Issue 11, p3220, 2 p.
Publication Year :: 2003
Abstract: A highly enantioselective skeletal rearrangement of symmetrically alpha,alpha-distributed alpha-amino aldehydes is developed, using a chiral organoluminum Lewis acid. The method provides a new entry to active alpha-hydroxy ketones and 1,2-amino alcohols.

Subjects :: Carbonyl compounds -- Optical properties
Amino acids -- Optical properties
Chemistry

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