Flurbiprofen (Ansaid) cross-sensitivity in an aspirin-sensitive asthmatic patient

Flurbiprofen (Ansaid) is a newly released nonsteroidal anti-inflammatory drug (NSAID) that is a potent inhibitor of prostaglandin synthesis. We report the first case (to our knowledge) of a flurbiprofen-induced asthmatic reaction confirmed by single-blind oral challenges. Cross-sensitivity and cross-desensitization between aspirin (ASA) and flurbiprofen were also demonstrated in this patient with rhinosinusitis and asthma, thus reinforcing the observation that NSAIDs capable of cyclooxygenase inhibition cross-react with ASA in producing characteristic respiratory reactions.
Flurbiprofen is a newly released nonsteroidal anti-inflammatory drug (NSAID) (Ansaid, Upjohn Co, Kalamazoo, MI) that has anti-inflammatory, analgesic, and antipyretic activities.[1] It is a potent cyclooxygenase inhibitor and thereby blocks [...]