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Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening
- Source :
- Journal of the American Chemical Society. Oct 1, 2003, Vol. 125 Issue 39, p11804, 2 p.
- Publication Year :
- 2003
-
Abstract
- The power of a tagged library approach for efficient forward chemical genetics is demonstrated, by expediting the connection of a hit compound to the affinity matrix by incorporating a linker directly to the library compounds before phenotypic screening. The study also elucidates the first novel small-molecule inhibitors for several ribosomal accessory proteins or their complex as their target.
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 125
- Issue :
- 39
- Database :
- Gale General OneFile
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.123524379