Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta(super 12,14) prostaglandin J2 (15-d-PGJ2)

Authors :: Paumi, Christian M.
Smitherman, Pamela K.
Townsend, Alan J.
Morrow, Charles S.
Source :: Biochemistry. March 2, 2004, Vol. 43 Issue 8, 2345-2352
Publication Year :: 2004
Abstract: A study is conducted to examine whether cytosolic glutathione S-transferases (GSTs), which catalyze glutathione conjugation, can reduce cellular activities of 15-d-PGJ2 or augment MRP-mediated attenuation of 15-d-PGJ2 activities. The study showed that the isozymes of GST have no effect on 15-d-PGJ2 cytotoxicity with or without MRP1.

Subjects :: Isoenzymes -- Analysis
Glutathione transferase -- Chemical properties
Glutathione transferase -- Research
Chemical reactions -- Analysis
Biological sciences
Chemistry

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