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14-helical folding in a cyclobutane-containing beta-tetrapeptide

Authors :
Izquierdo, Sandra
Kogan, Marcelo J.
Parella, Teodor
Moglioni, Albertina G.
Branchadell, Vicenc
Giralt, Ernest
Ortuno, Rosa M.
Source :
Journal of Organic Chemistry. July 23, 2004, Vol. 69 Issue 15, 5093-5099
Publication Year :
2004

Abstract

The productive synthesis of tetrapeptide containing cyclobutane and beta-alanine sediments is explained. Analytical computations predict a most stable folded conformation corresponding to a 14-helix stabilized by a hydrogen bond.

Subjects

Subjects :
Protein folding -- Analysis
Peptides -- Chemical properties
Peptides -- Research
Biological sciences
Chemistry

Details

Language :
English
ISSN :
00223263
Volume :
69
Issue :
15
Database :
Gale General OneFile
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.123065787

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