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Mammalian SIRT1 represses forkhead transcription factors
- Source :
- Cell. Feb 20, 2004, Vol. 116 Issue 4, 551-563
- Publication Year :
- 2004
-
Abstract
- The deacetylation and repression of the activity of forkhead transcription factor - Foxo3a and other mammalian forkhead factors by the mammalian SIR2 ortholog SIRT1 is reported. The speculation over the down regulation of the two classes of damage - responsive mammalian factors, favoring longer life - span under specific environmental conditions is presented.
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 116
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.123044366