Mammalian SIRT1 represses forkhead transcription factors

The deacetylation and repression of the activity of forkhead transcription factor - Foxo3a and other mammalian forkhead factors by the mammalian SIR2 ortholog SIRT1 is reported. The speculation over the down regulation of the two classes of damage - responsive mammalian factors, favoring longer life - span under specific environmental conditions is presented.