Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-Camphor, the substrate for P450cam

The structure of the cytochrome P450cin-substrate complex is reported and compared with the structure of cytochrome P450cam. The cytochrome P450cin uses a flavodoxin-like redox partner to reduce the heme iron rather than more traditional ferrodoxin-like Fe2S2 redox partner used by cytochrome P450cam and many other bacterial p450s.