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Mutational analysis of ABCG2: role of the GXXXG motif
- Source :
- Biochemistry. July 27, 2004, Vol. 43 Issue 29, 9448-9455
- Publication Year :
- 2004
-
Abstract
- The dimerization motif GXXXG found in the first transmembrane (TM) of the ABCG2 protein is studied by substituting glycine residues with leucine or alanine. The GXXXG motif facilitates dimerization by allowing packing of the helices though it does not induce dimerization single-handedly.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 43
- Issue :
- 29
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.122870050