Back to Search
Start Over
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex
- Source :
- Cell. July 23, 2004, Vol. 118 Issue 2, 203-216
- Publication Year :
- 2004
-
Abstract
- The biochemical purification of Toca-1 (transducer of Cdc42-dependent actin assembly) as an essential component of the Cdc42 pathway is described. It is found that in this model, activated Cdc42 interacts with both Toca-1 and the N-WASP-WIP complex, and these interactions lead to the activation of N-WASP, which in turn stimulates actin nucleation through the Arp2/3 complex.
- Subjects :
- Nucleation -- Research
Actin -- Research
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 118
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.122678256