Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein

Authors :: Hokenson, Mark J.
Uversky, Vladimir N.
Goers, John
Yamin, Ghiam
Munishkina, Larissa A.
Fink, Anthony L.
Source :: Biochemistry. April 20, 2004, Vol. 43 Issue 15, 4621-4633
Publication Year :: 2004
Abstract: A study was conducted to analyze the structural and fibrillation properties of a series of alpha-synuclein mutants. The result shows that the degree of inhibition of fibrillation by MetO alpha-synuclein is proportional to the number of oxidized methionines.

Subjects :: Biochemistry -- Research
Methionine -- Properties
Methionine -- Research
Biological sciences
Chemistry

Tools