Parallel genotyping of over 10.000 SNPs using a one-primer assay on a high-density oligonucleotide array

A high-throughput genotyping platform is presented that uses a one-primer assay to genotype offer 10,000 single nucleotide polymorphisms (SNPs) per individual on a single oligonucleotide array. This approach uses restriction digestion to fractionate the genome, followed by amplification of a specific fractionated subset of the genome.