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Probing Hydrogen-bonding interactions in the active site of medium-chain Acyl-CoA Dehydrogenase using Raman spectroscopy

Authors :
Wu, Jiaquan
Luo, Lian
Stephens, Avery W.
Stankovich, Marian T.
Tonge, Peter J.
Bell, Alasdair F.
Source :
Biochemistry. Oct 14, 2003, Vol. 42 Issue 40, 11846-11856
Publication Year :
2003

Abstract

The role of the oxyanion hole in Mechanistic studies on the medium-chain enzyme (MCAD) catalysis is been elaborated using a combination of kinetic, Raman spectroscopy, and redox combination of measurements. Numerous studies and their respective results concerned with the same are mentioned.

Details

Language :
English
ISSN :
00062960
Volume :
42
Issue :
40
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.121030728