Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: Differences between Torpedo and muscle-type AChR

Authors :: Navedo, Manuel
Nieves, Madeline
Rojas, Legier
Lasalde-Dominicci, Jose A.
Source :: Biochemistry. Jan 13, 2004, Vol. 43 Issue 1, 78-84
Publication Year :: 2004
Abstract: Alpha-TM3 domain of the muscle-type AChR is studied in detail by examining functional consequences of single tryptophan substitutions at five conserved positions. The results indicated that tryptophan substitution directly affects ion-channel gating, primarily the channel closing rate.

Subjects :: Tryptophan -- Chemical properties
Tryptophan -- Structure
Molecular structure -- Analysis
Biological sciences
Chemistry

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