Asymmetric synthesis of novel thioiso dideoxynucleosides with exocyclic methylane an potential antiviral agents

Authors :: Gunaga, Prashantha
Baba, Masanori
Jeong, Lak Shin
Source :: Journal of Organic Chemistry. April 30, 2004, Vol. 69 Issue 9, 3208-3211
Publication Year :: 2004
Abstract: Novel thioiso pyrimidine and purine nucleosides substituted with exocyclic methylane is synthesized starting from D-xylene. The glycosyl donor was synthesized from D-xylose, using cyclization of dimensylate with sodium sulfide as a key step.

Subjects :: Biosynthesis -- Analysis
Xylene -- Analysis
Nucleosides -- Analysis
Antiviral agents -- Analysis
Biological sciences
Chemistry

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