Vasopressin receptor antagonists: will the 'vaptans' fulfill their promise?

Authors :: Francis, Gary S.
Tang, W. H. Wilson
Source :: JAMA, The Journal of the American Medical Association. April 28, 2004, Vol. 291 Issue 16, p2017, 2 p.
Publication Year :: 2004
Abstract: The antidiuretic hormone arginine vasopressin (AVP) is a powerful vasoconstrictor that modulates free water transport in the kidney and has an important role in the normal regulation of cardiovascular physiology. The increasing concentrations of plasma AVP within the physiologically relevant range can cause vasoconstriction in patients with advanced heart failure.