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High frequency of mutations of the PIK3CA gene in human cancers

Authors :
Samuels, Yardena
Wang, Zhenghe
Bardelli, Alberto
Silliman, Natalie
Ptak, Janine
Szabo, Steve
Yan, Hai
Gazdar, Adi
Powell, Steven M.
Riggins, Gregory J.
Willson, James K.V.
Markowitz, Sanford
Kinzler, Kenneth W.
Vogelstein, Bert
Velculescu, Victor E.
Source :
Science. April 23, 2004, Vol. 304 Issue 5670, p554, 1 p.
Publication Year :
2004

Abstract

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival, and motility (1-3). To determine if PI3Ks are genetically altered in tumorigenesis, [...]

Details

Language :
English
ISSN :
00368075
Volume :
304
Issue :
5670
Database :
Gale General OneFile
Journal :
Science
Publication Type :
Academic Journal
Accession number :
edsgcl.116451413