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Compact CT/SPECT small-animal imaging system

Authors :
Kastis, George A.
Furenlid, Lars R.
Wilson, Donald W.
Peterson, Todd E.
Barber, H. Bradford
Barrett, Harrison H.
Source :
IEEE Transactions on Nuclear Science. Feb, 2004, Vol. 51 Issue 1, p63, 5 p.
Publication Year :
2004

Abstract

We have developed a dual-modality CT/SPECT imaging system for small-animal imaging applications. The X-ray system comprises a commercially available micro-focus X-ray tube and a CCD-based X-ray camera. X-ray transmission measurements are performed based on cone-beam geometry. Individual projections are acquired by rotating the animal about a vertical axis in front of the CCD detector. A high-resolution CT image is obtained after reconstruction using an ordered subsets-expectation maximization (OS-EM) reconstruction algorithm. The SPECT system utilizes a compact semiconductor camera module previously developed in our group. The module is mounted perpendicular to the X-ray tube/CCD combination. It consists of a 64 x 64 pixellated CdZnTe detector and a parallel-hole tungsten collimator. The field of view is 1 square inch. Planar projections for SPECT reconstruction are obtained by rotating the animal in front of the detector. Gamma-ray and X-ray images are presented of phantoms and mice. Procedures for merging the anatomical and functional images are discussed. Index Terms--Biomedical imaging, cadmium zinc telluride (CdZnTe), multimodality imaging, single-photon emission computed tomography, small-animal imaging.

Details

Language :
English
ISSN :
00189499
Volume :
51
Issue :
1
Database :
Gale General OneFile
Journal :
IEEE Transactions on Nuclear Science
Publication Type :
Academic Journal
Accession number :
edsgcl.116407040