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Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFα

Authors :
van der Heijden, J
de Jong, MC
Dijkmans, BAC
Lems, WF
Oerlemans, R
Kathmann, I
Schalkwijk, CG
Scheffer, GL
Scheper, RJ
Jansen, G
Source :
Annals of the Rheumatic Diseases. February 2004, Vol. 63 Issue 2, p138, 6 p.
Publication Year :
2004

Abstract

Objective: To determine whether overexpression of cell membrane associated drug efflux pumps belonging to the family of ATP binding cassette (ABC) proteins contributes to a diminished efficacy of sulfasalazine (SSZ) [...]

Subjects

Subjects :
Health

Details

Language :
English
ISSN :
00034967
Volume :
63
Issue :
2
Database :
Gale General OneFile
Journal :
Annals of the Rheumatic Diseases
Publication Type :
Periodical
Accession number :
edsgcl.112941601