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Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men
- Source :
- The Journals of Gerontology, Series A. Jan, 2004, Vol. 59 Issue 1, p10, 6 p.
- Publication Year :
- 2004
-
Abstract
- We investigated the association of vitamin D receptor (VDR) genotype with fat-free mass (FFM) in a cohort of 302 older (aged 58-93 years) Caucasian men who underwent body composition analysis by dual-energy X-ray absorptiometry, and completed questionnaires addressing comorbidities, physical activity, and dietary intake. All participants were genotyped for a VDR translation start site (FokI) polymorphism [FF (37.7%), Ff (48.4%), and ff (13.9%)] and the previously studied BsmI polymorphism [BB (24.9%), Bb (37.7%), and bb (37.4%)]. The BsmI polymorphism was not associated with FFM in any analysis; however, the Fokl polymorphism was significantly associated with total FFM, appendicular FFM, and relative (kg/[m.sup.2]) appendicular FFM (all p < .05), with the FF group demonstrating significantly lower FFM than the Ff and ff groups (e.g., total FFM: FF = 57.6 [+ or -] 0.4, Ff = 59.4 [+ or -] 0.4, if= 59.4 [+ or -] 0.7 kg; p < .02). Age-adjusted logistic regression revealed a 2.17-fold higher risk for sarcopenia (defined previously as appendicular FFM
- Subjects :
- Calcifediol
Alfacalcidol
Vitamin D
Sarcoma
Aged men
Health
Seniors
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 59
- Issue :
- 1
- Database :
- Gale General OneFile
- Journal :
- The Journals of Gerontology, Series A
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.112793892