An endogenous electrophile that modulates the regulatory mechanism of protein turnover: inhibitory effects of 15-deoxy-delta(sup)12,14-prostaglandin J(sub)2 on proteasome

Results indicate that 15-deoxy-delta(sup)12,14-prostaglandin J(sub)2 may modulate proteasome-dependent regulation of cellular functions, which in turn may be involved in the accumulation of p53 and subsequent induction of apoptosis induced by 15-deoxy-delta(sup)12,14-prostaglandin J(sub)2.