Trancriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8

Authors :: Henry, Karl W.
Wyce, Anastasia
Lo, Wan-Sheng
Duggan, Laura J.
Emre, N. C. Tolga
Kao, Cheng-Fu
Pillus, Lorraine
Shilatifard, Ali
Osley, Mary Ann
Berger, Shelley L.
Source :: Genes & Development. Nov 1, 2003, Vol. 17 Issue 21, 2648-2663
Publication Year :: 2003
Abstract: Research has been conducted on histone H2B. The authors present the evidence for histone's ubiquitylation and deubiquitylation during gene activation, and identify H2B deubiquitylating enzyme in the Spt-Ada-Gcn5-Acetyltransferase complex.

Subjects :: Genetic regulation -- Physiological aspects
Ubiquitin -- Genetic aspects
Genetic transcription -- Physiological aspects
Histones -- Genetic aspects
Genetic research -- Analysis
Biological sciences

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