Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse

Authors :: Barbara, G
De Giorgio, R
Stanghellini, V
Corinaldesi, R
Cremon, C
Gerard, N
Gerard, C
Grady, EF
Bunnett, NW
Blennerhassett, PA
Collins, SM
Source :: Gut. October 2003, Vol. 52 Issue 10, p1457, 8 p.
Publication Year :: 2003
Abstract: Background and aims: Substance P (SP) release from sensory nerves induces neurogenic inflammation. Neutral endopeptidase (NEP) degrades SP, thereby limiting its proinflammatory effects. Intestinal inflammation following Trichinella spiralis infection markedly [...]

Subjects :: Colorectal diseases -- Physiological aspects
Proteases -- Physiological aspects
Inflammation -- Physiological aspects
Roundworm infections -- Physiological aspects
Substance P -- Physiological aspects
Gastrointestinal diseases -- Physiological aspects
Mice -- Physiological aspects
Health
Physiological aspects

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