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FNR-mediated oxygen-responsive regulation of the nrdDG operon of Escherichia coli
- Source :
- Journal of Bacteriology. Sept, 2003, Vol. 185 Issue 17-18, p5310, 4 p.
- Publication Year :
- 2003
-
Abstract
- Transcription of the nrdDG operon, which encodes the class III nucleotide reductase, which is only active under anaerobic conditions, was strongly induced after a shift to anaerobiosis. The induction was completely dependent on the transcriptional activator FNR and was independent of the ArcA-ArcB two-component response regulator system. The nrdD transcript start site was mapped to a position immediately downstream of two FNR binding sites. Transcription of the other two nucleotide reductase operons, nrdAB and nrdEF, did not respond to oxygen conditions in a wild-type background, but nrdAB expression was increased in the fnr mutant under anaerobic conditions.
- Subjects :
- Oxygen -- Physiological aspects
Gene mutations -- Physiological aspects
Genetic transcription -- Physiological aspects
Anaerobiosis -- Physiological aspects
Gene expression -- Physiological aspects
Nucleotides -- Genetic aspects
Operons -- Genetic aspects
Bacteriology -- Research
Biological sciences
Subjects
Details
- Language :
- English
- ISSN :
- 00219193
- Volume :
- 185
- Issue :
- 17-18
- Database :
- Gale General OneFile
- Journal :
- Journal of Bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.108694489