Selective attenuation of the extrinsic limb of the tissue factor-driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor

A combinatorial library derived peptide, which binds to the extracellular domain of tissue factor, exhibits selective and quantitatively limited attenuation of factor X and the extrinsic limb of the coagulation protease cascades. Data indicate that such peptides provide attenuation of thrombotic risk on a long-term basis.