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N-glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor
- Source :
- Biochemistry. Sept 2, 2003, Vol. 42 Issue 34, 10333-10341
- Publication Year :
- 2003
-
Abstract
- Results indicate that the receptor activity modifying protein-3 (RAMP-3) is assembled with the calcitoni receptor-like receptor (CRLR) to yield a multiple N-glycosylated species using 2 to 4 consensus sites. Data show that inefficient use of Asn28 and Asn57 consensus sites result in the expression of multiple N-glycosylated RAMP3 species and that N-glycans participate in CRLR/RAMP3 receptor's function.
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 42
- Issue :
- 34
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.108143303