A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

Authors :: Ariyoshi, Mariko
Schwabe, John W. R.
Source :: Genes & Development. August 1, 2003, Vol. 17 Issue 15, 1909-1920
Publication Year :: 2003
Abstract: Research has been conducted on Spen proteins which regulate transcriptional effector expression in diverse signaling pathway. Results demonstrate that these proteins play important role in the transcriptional repression complex in both nuclear receptor and Notch signaling pathways.

Subjects :: Gene expression -- Physiological aspects
Genetic transcription -- Physiological aspects
RNA -- Genetic aspects
Proteins -- Genetic aspects
Genetic regulation -- Analysis
Genetic research -- Analysis
Biological sciences

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