FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

Authors :: Wehrens, Xander H. T.
Lehnart, Stephan E.
Huang, Fannie
Vest, John A.
Reiken, Steven R.
Mohler, Peter J.
Sun, Jie
Guatimosim, Silvia
Song, Long-Sheng
Rosemblit, Nora
D'Armiento, Jeanine M.
Napolitano, Carlo
Memmi, Mirella
Priori, Silvia G.
Lederer, W. J.
Marks, Andrew R.
Source :: Cell. June 27, 2003, Vol. 113 Issue 7, 829-840
Publication Year :: 2003
Abstract: Research has been conducted on the common cause of sudden cardiac death, arrhythmias. The authors suggest that ryanodine receptor channels can trigger fatal cardial arrhythmias explaining catecholaminergic polymorphic venticular tachycardia.

Subjects :: Ventricular tachycardia -- Causes of
Genetic polymorphisms -- Physiological aspects
Catecholamines -- Physiological aspects
Arrhythmia -- Causes of
Binding proteins -- Physiological aspects
Binding proteins -- Genetic aspects
Heart muscle -- Genetic aspects
Heart muscle -- Physiological aspects
Cardiac arrest -- Causes of
Calcium channels -- Physiological aspects
Cell research -- Analysis
Biological sciences

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