The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis

Research reveals the operon for the fumarate reductase contains three genes, including the haemoprotein in Bacteroides fragilis. The genes encode the cytochrome, iron-sulfur cluster protein and flavoprotein of the fumarate reductase. Data indicate that fumarate reductase is required for both energy metabolism and succinate biosynthesis in these bacteria.