Butyrate downregulates [α.sub.2][β.sub.1] integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines. (Colon)

Authors :: Buda, A.
Qualtrough, D.
Jepson, M.A.
Martines, D.
Paraskeva, C.
Pignatelli, M.
Source :: Gut. May 2003, Vol. 52 Issue 5, p729, 6 p.
Publication Year :: 2003
Abstract: Background: lntegrins mediate cell matrix adhesion and regulate cell growth and survival. In colonic epithelial cells, [α.sub.2][β.sub.1] integrin controls glandular differentiation and proliferation. Bulyrate stimulates differentiation and induces apoptosis in [...]

Subjects :: Colorectal cancer -- Physiological aspects
Fatty acids -- Physiological aspects
Biological control systems -- Physiological aspects
Cancer cells -- Physiological aspects
Apoptosis -- Physiological aspects
Health
Physiological aspects

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