Back to Search
Start Over
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion
- Source :
- The Journal of Cell Biology. March 31, 2003, Vol. 160 Issue 7, p1009, 7 p.
- Publication Year :
- 2003
-
Abstract
- The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly understood. Here, we show that the urokinase plasminogen activator receptor-associated protein (uPARAP)/Endo180, a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key player in this process. Fibroblasts from mice with a targeted deletion in the uPARAP/Endo180 gene displayed a near to complete abrogation of collagen endocytosis. Furthermore, these cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen. These studies identify a central function of uPARAP/ Endo180 in cellular collagen interactions.
Details
- Language :
- English
- ISSN :
- 00219525
- Volume :
- 160
- Issue :
- 7
- Database :
- Gale General OneFile
- Journal :
- The Journal of Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.100880105