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Patient knowledge of fecal calprotectin in inflammatory bowel disease (IBD): An observational study in Mexico [version 2; peer review: 2 approved]

Authors :
Brenda Maldonado-Arriaga
Sergio Sandoval-Jiménez
Juan Rodríguez-Silverio
Sofía Lizeth Alcaráz- Estrada
Tomás Cortés-Espinosa
Rebeca Pérez-Cabeza de Vaca
Jonathan Shaw
Paul Mondragón-Terán
Cecilia Hernández-Cortez
Juan Antonio Suárez-Cuenca
Graciela Castro-Escarpulli
Author Affiliations :
<relatesTo>1</relatesTo>Laboratorio de Metabolismo Experimental e Investigación Clínica; División de Investigación Clínica, ISSSTE, Félix Cuevas 540, Col del Valle Sur, Benito Juárez, Ciudad de México, 03229, Mexico<br /><relatesTo>2</relatesTo>Hospital General de 2A Troncoso, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico<br /><relatesTo>3</relatesTo>Laboratorio de Investigación Clínica y Ambiental. Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Calle Plan de Ayala s/n, Santo Tomás, Miguel Hidalgo, Ciudad de México, 11340, Mexico<br /><relatesTo>4</relatesTo>Escuela Superior de Medicina, Instituto Politécnico Nacional, Miguel Hidalgo, Ciudad de México, 11340, Mexico<br /><relatesTo>5</relatesTo>Unidad de Análisis y Referencia Virológica, ISSSTE, Félix Cuevas 540, Col del Valle Sur, Benito Juárez, Ciudad de México, 03229, Mexico<br /><relatesTo>6</relatesTo>Clínica de Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, ISSSTE, Félix Cuevas 540, Col del Valle Sur, Benito Juárez, Ciudad de México, 03229, Mexico<br /><relatesTo>7</relatesTo>Coordinación de Investigación y División de Investigación Biomédica, ISSSTE, Félix Cuevas 540, Col del Valle Sur, Benito Juárez, Ciudad de México, 03229, Mexico<br /><relatesTo>8</relatesTo>Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield Medical School, Broomhall, Sheffield, S10 2TG, UK<br /><relatesTo>9</relatesTo>Laboratorio de Bioquímica Microbiana, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Calle Plan de Ayala s/n, Santo Tomás, Miguel Hidalgo, Ciudad de México, 11340, Mexico
Source :
F1000Research. 9:1496
Publication Year :
2021
Publisher :
London, UK: F1000 Research Limited, 2021.

Abstract

Background: Fecal calprotectin (FC) can be a valuable tool to optimize health care for patients with inflammatory bowel disease (IBD). The objective of this observational study was to determine the level of knowledge of the FC test in Mexican patients with IBD. Methods: A self-report questionnaire was distributed via Facebook to patients with IBD. The survey consisted of 15 questions in two categories: the first category assessed knowledge of IBD diagnosis, and the second category assessed knowledge of the FC test. Results: In total, 460 patients with IBD participated, of which 83.9% (386) had ulcerative colitis (UC) and 16.0% (74) had Crohn’s disease (CD). Regarding IBD diagnosis, 41.9% of participants stated that they did not know of a non-invasive test for fecal matter to identify inflammation of the colon. Regarding the FC test, 57.5% (UC) and 58.1% (CD) stated that they did not know about the test. Additionally, 65.8% (UC) and 51.3% (CD) of participants stated that they had never received the FC test and 82.6% (UC) and 77.0% (CD) recognized that the FC test was difficult to access in their medical practice. Furthermore, 66% (UC) and 52.7% (CD) of participants noted that their specialist doctor had never suggested the FC test to them, yet 89.1% (UC) and 87.8% (CD) stated that they would prefer FC analysis for their IBD follow-up assessments. Conclusions: There is little knowledge of the FC biomarker among Mexican patients with IBD. This suggests the need for greater dissemination of its use and scope as a biomarker in IBD.

Details

ISSN :
20461402
Volume :
9
Database :
F1000Research
Journal :
F1000Research
Notes :
Revised Amendments from Version 1 The changes made were in the area of ​​methods, highlighting the following: According to a previous study by Yamamoto et al., 2015, the prevalence of IBD in Mexico is 150,000, and considering an expected prevalence difference and an acceptable error of 5 %, the sample size calculations were performed, this in order to clarify how the sample size calculation was performed. On the other hand, in the area of ​​discussion, the reason why there were more cases of Ulcerative Colitis and why there was greater participation of women was added, adding that even in Mexico it is still a challenge to understand the real number of cases of IBD. The predominance of women, this imbalance may be due to environmental factors such as the use of oral contraceptives, psychosocial stress, dietary factors, among others. It was also added that the information on this Calprotectin test cannot be omitted, since national and international clinical guidelines for the diagnosis and treatment of IBD in the adult population recommend the use of the fecal calprotectin test in various clinical settings, including initial diagnosis, diagnosis of relapse, and response to treatment. And finally, internet access was added as a limitation, since it could have had an impact on the number of participants who answered the questionnaire. Everything added was justified with different bibliographic references., , [version 2; peer review: 2 approved]
Publication Type :
Academic Journal
Accession number :
edsfor.10.12688.f1000research.27629.2
Document Type :
research-article
Full Text :
https://doi.org/10.12688/f1000research.27629.2