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A case report of simultaneous PML-IRIS during corticosteroids tapering in a patient with an anti-synthetase syndrome [version 1; referees: 2 approved, 1 approved with reservations]
- Source :
- F1000Research. 2:283
- Publication Year :
- 2013
- Publisher :
- London, UK: F1000 Research Limited, 2013.
-
Abstract
- We report a case of simultaneous progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-IRIS) during corticosteroid tapering in a patient with an anti-synthetase syndrome. We describe the challenges associated with the diagnosis and the management of this emerging inflammatory neurological condition in this immunocompromised patient with a severe rheumatic disease. We highlight that, in the setting of IRIS, the low-level of the JC virus viral load requires a sensitive PCR assay before excluding PML.
Details
- ISSN :
- 20461402
- Volume :
- 2
- Database :
- F1000Research
- Journal :
- F1000Research
- Notes :
- [version 1; referees: 2 approved, 1 approved with reservations]
- Publication Type :
- Academic Journal
- Accession number :
- edsfor.10.12688.f1000research.2.283.v1
- Document Type :
- case-report
- Full Text :
- https://doi.org/10.12688/f1000research.2-283.v1