Huntington’s Disease : Pathogenic Mechanisms and Implications for Therapeutics

Huntington's disease (HD) is one of the most common dominantly inherited neurodegenerative disorders, characterized by a clinical trial of movement disorder, cognitive deficits, and psychiatric symptoms. Huntington's Disease: Pathogenic Mechanisms and Implications for Therapeutics, reviews the most up-do-date content on HD pathogenic mechanisms and cutting-edge testing of therapeutic strategies for HD. Chapters explore areas such as, normal huntingtin biology in brain development and function, genetic modifiers of HD in patients, molecular pathogenic mechanism in HD, and mechanisms underlying selective neuronal vulnerabilityReviews the clinical course and genetics of HDReviews the biology of human huntingtin and HD-relevant cell typesReviews the wide range of pathobiology associated with mutant huntingtinReviews genetic studies of HD and how these studies are informing the development of new therapeutic approachesReviews new tools and model systems for basic and translational research in HD, including new human-derived model systems, as well as systems biology and artificial intelligence–driven approachesProvides an overview of new therapeutic approaches and current clinical programs in HD