Back to Search Start Over

Tumor Suppressor Par-4 : Structural Features, Molecular Mechanisms and Function

Authors :
Vivek M. Rangnekar
Vivek M. Rangnekar
Publication Year :
2022

Abstract

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

Subjects

Subjects :
Tumor suppressor proteins

Details

Language :
English
ISBNs :
9783030735715 and 9783030735722
Database :
eBook Index
Journal :
Tumor Suppressor Par-4 : Structural Features, Molecular Mechanisms and Function
Publication Type :
eBook
Accession number :
3137456