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Tumor Suppressor Par-4 : Structural Features, Molecular Mechanisms and Function
- Publication Year :
- 2022
-
Abstract
- Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.
- Subjects :
- Tumor suppressor proteins
Subjects
Details
- Language :
- English
- ISBNs :
- 9783030735715 and 9783030735722
- Database :
- eBook Index
- Journal :
- Tumor Suppressor Par-4 : Structural Features, Molecular Mechanisms and Function
- Publication Type :
- eBook
- Accession number :
- 3137456