Circulating lipoproteins are a crucial component of host defense against invasive Salmonella typhimurium infection.

Authors :: Mihai G Netea
Leo A B Joosten
Monique Keuter
Frank Wagener
Anton F H Stalenhoef
Jos W M van der Meer
Bart Jan Kullberg
Source :: PLoS ONE, Vol 4, Iss 1, p e4237 (2009)
Publication Year :: 2009
Publisher :: Public Library of Science (PLoS), 2009.
Abstract: BACKGROUND: Circulating lipoproteins improve the outcome of severe Gram-negative infections through neutralizing lipopolysaccharides (LPS), thus inhibiting the release of proinflammatory cytokines. METHODS/PRINCIPAL FINDINGS: Low density lipoprotein receptor deficient (LDLR-/-) mice, with a 7-fold increase in LDL, are resistant against infection with Salmonella typhimurium (survival 100% vs 5%, p

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