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Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers

Authors :
Hiroto Hatakeyama
Sherry Y. Wu
Yasmin A. Lyons
Sunila Pradeep
Wanqin Wang
Qian Huang
Karem A. Court
Tao Liu
Song Nie
Cristian Rodriguez-Aguayo
Fangrong Shen
Yan Huang
Takeshi Hisamatsu
Takashi Mitamura
Nicholas Jennings
Jeajun Shim
Piotr L. Dorniak
Lingegowda S. Mangala
Marco Petrillo
Vladislav A. Petyuk
Athena A. Schepmoes
Anil K. Shukla
Madeline Torres-Lugo
Ju-Seog Lee
Karin D. Rodland
Anna Fagotti
Gabriel Lopez-Berestein
Chun Li
Anil K. Sood
Source :
Cell Reports, Vol 17, Iss 6, Pp 1621-1631 (2016)
Publication Year :
2016
Publisher :
Elsevier, 2016.

Abstract

Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.

Details

Language :
English
ISSN :
22111247
Volume :
17
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Cell Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.ffc25263dff34e019722e07e71d9ce5f
Document Type :
article
Full Text :
https://doi.org/10.1016/j.celrep.2016.10.020