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In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem
- Source :
- Nano-Micro Letters, Vol 10, Iss 4, Pp 1-11 (2018)
- Publication Year :
- 2018
- Publisher :
- SpringerOpen, 2018.
-
Abstract
- Abstract Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem 64Cu-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.
Details
- Language :
- English
- ISSN :
- 23116706 and 21505551
- Volume :
- 10
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Nano-Micro Letters
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.ffb0beb85cea46b888c0ed8637ff7278
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s40820-018-0216-2