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A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams

Authors :
Alexander V. Aksenov
Dmitrii A. Aksenov
Igor A. Kurenkov
Alexander V. Leontiev
Nicolai A. Aksenov
Source :
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10213 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
24
Issue :
12
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.ff912f2945018029f67181a0471b
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms241210213