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SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease

Authors :
Feng Gao
Fang Li
Jianhao Wang
Hang Yu
Xiang Li
Hongyu Chen
Jiabei Wang
Dongdong Qin
Yiyi Li
Songyan Liu
Xi Zhang
Zhi-Hao Wang
Source :
Biosensors, Vol 13, Iss 9, p 880 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.

Details

Language :
English
ISSN :
20796374
Volume :
13
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Biosensors
Publication Type :
Academic Journal
Accession number :
edsdoj.ff1d29852254cb6a442f92d7238a02e
Document Type :
article
Full Text :
https://doi.org/10.3390/bios13090880