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Specific antibody deficiency to pneumococcal polysaccharide in a young adult with recurrent respiratory infections: a case report

Specific antibody deficiency to pneumococcal polysaccharide in a young adult with recurrent respiratory infections: a case report

Authors :
Naoto Ishimaru
Yohei Kanzawa
Takahiro Nakajima
Kayoko Okamura
Eiichiro Sando
Isao Ito
Saori Kinami
Hisashi Ohnishi
Source :
Monaldi Archives for Chest Disease (2022)
Publication Year :
2022
Publisher :
PAGEPress Publications, 2022.

Abstract

Specific antibody deficiency against pneumococcal serotypes was detected in a patient with recurrent episodes of fever. A 21-year-old man presented with a two-month history of recurrent episodes of fever and shaking chills. He was diagnosed with recurrent episodes of pneumonia caused by Streptococcus pneumoniae serotype 19A and treated with amoxicillin. Serotype-specific antibodies were not produced against most of the serotypes, which were consistent with moderate specific antibody deficiency. After pneumococcal 13-valent conjugate vaccination and pneumococcal polysaccharide vaccination, he adequately responded to the infecting serotype with an antibody titer of 1.1 µg/mL. There were eventually no recurrent episodes of fever with pneumonia.

Details

Language :
English
ISSN :
11220643 and 25325264
Database :
Directory of Open Access Journals
Journal :
Monaldi Archives for Chest Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.ff1c2ce710ba419c91fabd02f38898b9
Document Type :
article
Full Text :
https://doi.org/10.4081/monaldi.2022.2454