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Robust temporal map of human in vitro myelopoiesis using single-cell genomics

Authors :
Clara Alsinet
Maria Nascimento Primo
Valentina Lorenzi
Erica Bello
Iva Kelava
Carla P. Jones
Roser Vilarrasa-Blasi
Carmen Sancho-Serra
Andrew J. Knights
Jong-Eun Park
Beata S. Wyspianska
Gosia Trynka
David F. Tough
Andrew Bassett
Daniel J. Gaffney
Damiana Alvarez-Errico
Roser Vento-Tormo
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The myeloid lineage is central to homeostasis and immunity. The authors provide an atlas of human iPSC-to-myeloid cell differentiation and demonstrate that the in vitro system recapitulates yolk sac differentiation, opening new avenues to human myelopoiesis.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.ff14b8d69b054e38a5e0e2b1247d1b45
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30557-4