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Relation Between EB Virus Infection and Curative Effect, Prognosis of Patients with Early-stage Extranodal Nasal-type NK/T-cell Lymphoma
- Source :
- Zhongliu Fangzhi Yanjiu, Vol 48, Iss 11, Pp 999-1005 (2021)
- Publication Year :
- 2021
- Publisher :
- Magazine House of Cancer Research on Prevention and Treatment, 2021.
-
Abstract
- Objective To explore the correlation of pretreatment EBV DNA load, EBV EA-IgA and VCA-IgA antibodies levels with the clinical characteristics, curative effect and prognosis of the patients with early-stage extranodal nasal-type NK/T-cell lymphoma (ENKTCL). Methods We analyzed the clinical features and prognostic factors of 78 ENKTCL patients. Results Positive rates of pretreatment EBV DNA, VCA-IgA and EA-IgA were 43.6%, 20.5% and 14.1%, respectively. EBV DNA was significantly associated with Ann Arbor stage, primary site, PTI and non-CR (all P < 0.05). VCA-IgA and EA-IgA were related to positive EBV DNA and non-CR (all P < 0.05). Multivariate analysis showed that age, EBV DNA and non-CR were independent prognostic factors for OS (all P < 0.05); age, EBV DNA, primary site and non-CR were independent prognostic factors for PFS (all P < 0.05). Conclusion The pretreatment positive EBV DNA is related to advanced Ann Arbor stage, PTI, primary extra-nasal subtypes of upper aerodigestive tract and poor response to treatment. The elevated levels of EA-IgA and VCA-IgA are related to positive EBV DNA and poor response to treatment. Pretreatment EBV DNA could be used for risk stratification and prognosis prediction of ENKTCL, while EA-IgA and VCA-IgA play limited role in guiding the prognosis of ENKTCL.
Details
- Language :
- Chinese
- ISSN :
- 10008578
- Volume :
- 48
- Issue :
- 11
- Database :
- Directory of Open Access Journals
- Journal :
- Zhongliu Fangzhi Yanjiu
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.ff0faae7a684d5eb3f253fa0f3b3469
- Document Type :
- article
- Full Text :
- https://doi.org/10.3971/j.issn.1000-8578.2021.21.0216