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An inner activation gate controls TMEM16F phospholipid scrambling

Authors :
Trieu Le
Zhiguang Jia
Son C. Le
Yang Zhang
Jianhan Chen
Huanghe Yang
Source :
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Publication Year :
2019
Publisher :
Nature Portfolio, 2019.

Abstract

TMEM16F is an enigmatic Ca2 + -activated phospholipid scramblase (CaPLSase) that passively transports phospholipids. Here authors identify an inner activation gate and its disruption profoundly alters TMEM16F phospholipid permeation.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
10
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.ff04ecc72037485988bec5dbf32407c6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-019-09778-7
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