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Consistent RNA sequencing contamination in GTEx and other data sets

Authors :
Tim O. Nieuwenhuis
Stephanie Y. Yang
Rohan X. Verma
Vamsee Pillalamarri
Dan E. Arking
Avi Z. Rosenberg
Matthew N. McCall
Marc K. Halushka
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples, which is corroborated in other data sets.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.fede4787d2dc40708b7ce5f17be141ab
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15821-9