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Gestational Diabetes Type 2: Variation in High-Density Lipoproteins Composition and Function

Authors :
Yael Pasternak
Tal Biron-Shental
Meital Ohana
Yael Einbinder
Nissim Arbib
Sydney Benchetrit
Tali Zitman-Gal
Source :
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6281 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Aims: Class A2 gestational diabetes mellitus (GDMA2) has short- and long-term effects on the mother and child. These may include abnormalities of placentation, damage to endothelial cells and cardiovascular disease. This research investigated the function and composition of high-density lipoproteins (HDL) among women with GDMA2 and their fetuses. Methods: Thirty pregnant women were recruited during admission for delivery. The function and expression of HDL, paraoxonase1 (PON1) and apolipoprotein A1 (APOA1) in the blood samples and the placental tissue were evaluated. The effect of HDL on migration of endothelial cells was measured in vitro. Results: Compared to normal pregnancy (NP), APOA1 in the maternal plasma of women with GDMA2 was decreased. More APOA1 and PON1 were released from HDL of women with GDMA2, compared to NP. Placental APOA1 and PON1 were decreased in GDMA2. For endothelial cells stimulated with TNFα, HDL cell migration was decreased when cells were evaluated with NP-HDL, as compared to GDMA2-HDL. Conclusions: GDMA2 affects the composition and function of HDL in plasma. Changes in HDL commonly seen in GDMA2 were observed in maternal and placental samples, but not in cord samples. These results might indicate a placental role in protecting the fetus by preserving the components and functions of HDL and require further investigation.

Details

Language :
English
ISSN :
14220067 and 16616596
Volume :
21
Issue :
17
Database :
Directory of Open Access Journals
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.fed916ccf5c4c48928daa2abf3eeca2
Document Type :
article
Full Text :
https://doi.org/10.3390/ijms21176281