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Pp65 antigenemia and cytomegalovirus diagnosis in patients with lupus nephritis: report of a series.

Authors :
Katia Lino
Natalia Trizzotti
Fabiana Rabe Carvalho
Rachel Ingrid Cosendey
Cintia Fernandes Souza
Evandro Mendes Klumb
Andrea Alice Silva
Jorge Reis Almeida
Source :
Brazilian Journal of Nephrology, Iss 0 (2018)
Publication Year :
2018
Publisher :
Sociedade Brasileira de Nefrologia, 2018.

Abstract

ABSTRACT Introduction: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). Objective: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. Methods: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia. The pp65 antigenemia assay, revealed by immunofluorescence, was correlated with clinical and laboratory findings. Results: We included 19 patients with a suspected unclear infection. A positivity for pp65 antigenemia was found in seven patients (36.8%). The mean age was 33.5 ± 11.2 years, 16 (84%) were females, and 16 (84%) were black. Lymphopenia, anemia, and higher scores of SLEDAI were significantly more common in pp65-positive patients. Five patients received antiviral therapy with ganciclovir. Although receiving specific CMV treatment, one patient died because of suspected CMV disease. Conclusions: Pp65 antigenemia might be relevant in SLE patients, and studies with a greater number of patients are needed in order to establish sensitivity and specificity of pp65 antigenemia in different clinical contexts of SLE patients.

Details

Language :
English, Portuguese
ISSN :
21758239
Issue :
0
Database :
Directory of Open Access Journals
Journal :
Brazilian Journal of Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.febbe1a9d6604dfeb547430d38ead4b8
Document Type :
article
Full Text :
https://doi.org/10.1590/2175-8239-jbn-3838