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The impact of erlotinib use in non-small-cell lung cancer patients treated in a private reference general hospital and in a private cancer clinic from 2005 to 2011

Authors :
Cinthia Leite Frizzera Borges Bognar
Sergio Daniel Simon
Rene Claudio Gansl
Roberto Abramoff
Marcelo Aisen
Gilberto de Lima Lopes Junior
Oren Smaletz
Stela Verzinhasse Peres
Jacques Tabacof
Source :
Einstein (São Paulo), Vol 13, Iss 2, Pp 215-220
Publisher :
Instituto Israelita de Ensino e Pesquisa Albert Einstein.

Abstract

ABSTRACT Objective: To report the demographic data and clinical outcomes of non-small-cell lung cancer patients exposed to erlotinib in any line of treatment. Methods: This was a retrospective cohort study of nonsmall-cell lung cancer patients from a reference general hospital and a private oncology clinic, who received erlotinib from 2005 to 2011. Statistical analysis was performed and we evaluated demographic data and response to treatment, by correlating the results of this first cohort published in Brazil with results of current literature. Results: A total of 44 patients were included; 65.9% were diagnosed with adenocarcinoma, and 63.6% had metastatic disease. The mean age was 63.3 years. The median follow-up was 47.9 months. Epidermal growth factor receptor mutation screening was performed in 22.7% of patients (n=10), with mutation present in 30% of patients. The median overall survival was 46.3 months, and there was a higher probability of survival at 60 months for females compared to males (29.4% versus 15.8%; p=0.042). The other variables did not present significant statistical difference. Conclusion: We collected the largest cohort of patients with non-small-cell lung cancer who have used erlotinib in Brazil to date, and demonstrated that outcomes of patients treated at our clinic during the study period were consistent with the results of current literature in similar patients.

Details

Language :
English, Portuguese
ISSN :
23176385 and 16794508
Volume :
13
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Einstein (São Paulo)
Publication Type :
Academic Journal
Accession number :
edsdoj.fea7ed0cef454363a5f252ec0fefd708
Document Type :
article
Full Text :
https://doi.org/10.1590/S1679-45082015AO3326